Apoptosis Related PDCD4: Promising Novel Biomarker Early Detection of Oral Cancer
نویسندگان
چکیده
Aim: This study aimed to investigate the potential role of PDCD4 gene, involved in progression oral potentially malign disorder (OPMD) and squamous cell carcinoma cancer (OSCC). Material Methods: The was conducted on saliva blood samples that were collected from OSCC (n=6), OPMD (n=6) patients, healthy individuals. expression determined by using qRT-PCR. Kruskal Wallis test performed estimate relationship between clinical characteristics patients. correlation patients groups tested with Rank Spearman test. Results: mRNA levels assessed 6 OSCCs, individuals blood. In both saliva, 6/6 (100%) underexpressed OSCC, while it 5/6 (83%) OPMD. mean value significantly downregulated than (p<0.05). rank obtained a p-value for 2 tail 0.024 (p < 0.05), which showed significant both, coefficient -0.530 strong negative downregülation OPMD, OSCC. Conclusion: level is correlated indicates liquid biopsies may have as diagnostic biomarker
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ژورنال
عنوان ژورنال: Ado klinik bilimler dergisi
سال: 2022
ISSN: ['1307-3540']
DOI: https://doi.org/10.54617/adoklinikbilimler.1091916